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21

2023-09

Little “Life” Makes Sense (V) | The Immune Scavenger—Macrophages

Macrophages are white blood cells residing in tissues, derived from monocytes, which in turn originate from precursor cells in the bone marrow. Both macrophages and monocytes are phagocytic cells that participate in both non-specific defense (innate immunity) and specific defense (cell-mediated immunity) within the body. Their primary functions include phagocytosing cellular debris and pathogens—either as tissue-resident or circulating cells—and activating lymphocytes and other immune cells to mount a response against these pathogens.

2023-09-21

He Yousheng

21

2023-09

Issue 1 | Sharing of CAR Positive Rate Testing Data

In 2010, two patients with hematologic malignancies became the first participants in a clinical trial of CAR-T cell therapy at the Perelman School of Medicine at the University of Pennsylvania, and their cancers achieved complete remission that same year. More than a decade later, research published in Nature and based on up to 10 years of follow-up data indicate that CAR-T cells can still be detected in patients’ bodies 10 years after infusion. Owing to their high selectivity, localized high concentrations, and customizable nature, cell therapies have ushered in a new chapter in cancer immunotherapy.

2023-09-21

He Yousheng

08

2023-09

Themed Salon | Antibody Discovery: The First Step in Developing Novel Antibody Drugs

Antibody therapeutics currently represent the fastest-growing segment within the biopharmaceutical industry and are a major focus of global drug discovery and development. This rapid advancement is driven by technological innovations, including diverse display technologies, transgenic humanized animal models, single-cell PCR, and single-cell sequencing.

2023-09-08

He Yousheng

06

2023-09

Little “Life” Makes Sense (IV) | The Advanced Intelligence Agent of Immunotherapy: Dendritic Cells

Dendritic cells (DCs) derive their name from the dendritic processes on their surface, which facilitate antigen capture and intercellular communication with other immune cells. As the most potent professional antigen-presenting cells (APCs), DCs efficiently engulf, process, and present antigens. Immature DCs exhibit robust migratory capacity, whereas mature DCs can effectively activate naïve T cells, thereby occupying a central role in initiating, regulating, and sustaining immune responses. Under normal conditions, DCs are present in low numbers, accounting for only about 1% of peripheral blood mononuclear cells in humans.

2023-09-06

He Yousheng

17

2023-08

Hycells Services | “True” Viral Neutralizing Antibody Testing

Currently, pseudovirus-based assays closely mimic physiological infection mechanisms and can largely replicate the in vivo therapeutic efficacy; however, there is a substantial discrepancy between neutralization assay results obtained with live viruses and those obtained with pseudoviruses. Therefore, live-virus neutralization assays are an indispensable component of antiviral drug and vaccine development.

2023-08-17

He Yousheng

16

2023-08

Little “Life” Makes Sense (III) | The Rising Star of Immunotherapy: γδ T Cells

Immune cells, commonly known as white blood cells, include lymphocytes and various phagocytic cells. They are defined as lymphocytes and other cells capable of recognizing antigens and mounting specific immune responses. Based on their development and migration patterns, surface molecular characteristics, and functional properties, lymphocytes can be classified into T lymphocytes, B lymphocytes, and natural killer (NK) cells.

2023-08-16

He Yousheng
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