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Sample Service

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Leukopak Collection Service

Leukopak is a concentrated blood fraction collected using a apheresis machine, primarily intended for the isolation of white blood cells (WBCs) from peripheral blood. WBCs are highly enriched in peripheral blood mononuclear cells (PBMCs), which consist mainly of T cells, B cells, NK cells, and monocytes. The WBC concentration in Leukopak is substantially higher—approximately 4–7 × 10^8 WBCs per milliliter—than that in whole blood, where the average is 5–7 × 10^6 WBCs per milliliter. In addition, the red blood cell (RBC) count in Leukopak is markedly reduced, with a ratio of about 2 RBCs to 1 WBC, whereas in whole blood the ratio is roughly 1,000 RBCs to 1 WBC. Moreover, the purity and quality of the WBC fraction in Leukopak are far superior to those in whole blood, typically containing more than 20-fold the amount of PBMCs. PBMCs are highly valued for their applications in immunotherapy research, cell therapy process development, and clinical settings. Consequently, WBCs have become the preferred starting material for cell therapy research and drug development.

PBMC Isolation Service

PBMC (peripheral blood mononuclear cell) refers to mononuclear cells in peripheral blood, including lymphocytes, monocytes, dendritic cells, and a small number of other cell types such as hematopoietic stem cells. Based on the source of the sample, PBMC can be classified as whole-blood–derived PBMC or apheresis–derived PBMC. Apheresis–derived PBMC is a component blood product obtained by leukapheresis using an apheresis machine; the majority of cells in this fraction are PBMC, with only a small proportion of granulocytes and erythrocytes.

CD3+ Cell Sorting Service

CD3 is an important leukocyte differentiation antigen that is expressed on the surface of nearly all T cells. It consists of four genetic loci and six polypeptide chains, and serves as a membrane-associated antigen that forms part of the T-cell antigen receptor (TCR). Upon antigen–TCR engagement, CD3 mediates intracellular signal transduction, regulates T-cell differentiation—including the lineage commitment and activation of helper T cells and cytotoxic T cells—facilitates cytokine secretion and apoptosis, and influences ligand-receptor interactions, thereby playing a critical role in the diverse functional activities of T cells.

CD4+ Cell Sorting Service

CD4 cells refer to T lymphocytes that express the CD4 molecule on their surface; they are a crucial type of immune cell in the human body. Because HIV primarily targets CD4+ T cells, the results of CD4 cell count testing play an important role in assessing the efficacy of AIDS treatment and evaluating the patient’s immune function.

CD4+ Naive T Cell Sorting Service

Among helper T cells, naïve CD4+ T cells that have not yet been stimulated by antigens are designated as Th0. Upon maturation and activation, these cells can execute a variety of antigen-dependent effector functions. Based on their distinct functional profiles, CD4+ T cells can be classified into several Th cell subsets, including Th1, Th2, Th3, Treg, Tr1, Tfh, Th17, Th9, and Th22. These Th subsets engage in intricate interplay and coordinate their activities to exert immunoregulatory effects, thereby maintaining homeostasis of the organism.

CD8+ cytotoxic T cells

CD8+ cytotoxic T cells are considered the primary effector cells of anti-tumor immunity. Their restricted and antigen-specific recognition of tumor-associated antigens (TA) via class I MHC molecules, combined with their ability to produce perforin and other cytotoxins upon activation, enables them to induce tumor cell death while sparing normal cells.

Cynomolgus monkey PBMC

Cynomolgus macaque peripheral blood mononuclear cells (PBMCs), owing to their high degree of similarity to the human immune system, have become an essential tool in drug development, immunotherapy, vaccine research, and other fields, particularly playing an irreplaceable role in preclinical studies of gene therapy and cell therapy.

Compliance Approval

Recruitment and Screening

Collect

Separation and preparation

Quality Control

Sample Delivery

Compliance Approval

In strict accordance with regulatory requirements set forth in the Regulations on the Administration of Human Genetic Resources, the Good Clinical Practice for Drug Clinical Trials, and other relevant laws and regulations, we conduct compliant project applications and approvals to comprehensively ensure that our services are lawful and compliant.

Recruitment and Screening

We have established stable partnerships with multiple recruitment agencies and a robust re-recruitment mechanism, rigorously screening donors based on nationality, occupation, health status, and other criteria to ensure sample quality from the very outset.

Collect

Establish long-term, stable partnerships with fully accredited and well-managed hospitals, equipped with dedicated personnel and specialized equipment to ensure the safety and stability of the entire blood-collection process.

Separation and preparation

Establish a stringent cell isolation and preparation system, employing standardized procedures to ensure the acquisition of high-purity, high-quality target cells.

Quality Control

Establish a comprehensive quality control system that ensures end-to-end recording and full traceability of all quality-control data, thereby guaranteeing the stability and reliability of service delivery.

Sample Delivery

Entrust a professionally qualified cold-chain logistics company to ensure the rapid and secure delivery of samples.

Crab-eating macaque （ Cynomolgus macaque , commonly known as the “stone crab monkey”) Due to their high degree of similarity to the human immune system, PBMCs have become an essential tool in drug development, immunotherapy, vaccine research, and other fields, playing an irreplaceable role especially in preclinical studies of gene therapy and cell therapy.

Major applications of cynomolgus monkey PBMCs (peripheral blood mononuclear cells) in biomedical research and the underlying reasons:

1. Highly similar to the human immune system

- The crab-eating macaque is a non-human primate (NHP) whose immune system—including T cells, B cells, and NK cells—is highly similar to that of humans, making it more valuable for preclinical research than rodent models such as mice.

- PBMCs (peripheral blood mononuclear cells) comprise lymphocytes (T, B, and NK cells) and monocytes, making them suitable for research in immunology, vaccine development, cell therapy, and other fields.

2. Ideal Models for Preclinical Drug Evaluation

- Drug safety assessment: Evaluating the impact of candidate drugs (such as antibodies and cell therapy products) on the immune system.

- Pharmacodynamic studies: assessing the immune responses elicited by vaccines and cancer immunotherapies, such as CAR-T cell therapy and PD-1 inhibitors.

- Toxicology studies: to determine whether a drug induces abnormal immune activation or suppression.

3. Applicable to gene therapy and cell therapy research

- Crab-eating macaque PBMCs can be used in preclinical studies of CAR-T, TCR-T, stem cell therapy, and other applications to evaluate the proliferation, cytotoxicity, cytokine release, and other characteristics of cell-based products.

- Due to the partial homology between the MHC (major histocompatibility complex) of cynomolgus monkeys and that of humans, their PBMCs can be used for studies of allogeneic immune responses.

4. Support for Infectious Disease and Vaccine Research

- Used to study the immune response following infection with viruses such as HIV, SARS-CoV-2, and influenza.

- Evaluate the immunogenicity of vaccines, such as mRNA vaccines and adenovirus-vector vaccines.

5. Mature standardized experimental system

- Crab-eating macaque PBMC The technologies for cell isolation, cryopreservation, and resuscitation are well established, enabling the stable supply of high-quality cells suitable for high-throughput screening and Good Laboratory Practice Compliance research.

[Crab-eating Macaque PBMC]

Cynomolgus monkey PBMCs are widely used in Drug discovery/development, analytical validation/development, and other immunology-related research Middle.

Sample Number	Delivery Specifications	Delivery Format
HYS-CMP010C	Cryopreserved cynomolgus monkey PBMCs, 10 million	Cryopreservation
HYS-CMP020C	Cryopreserve crab-eating macaque PBMCs, 20 million	Cryopreservation
HYS-CMP100C	Cryopreserve crab-eating macaque PBMCs, 100 million	Cryopreservation
HYS-CMP010C-LY	Cryopreserved PBMCs from rhesus monkeys, 10 million	Cryopreservation
HYS-CMP020C-LY	Cryopreserved PBMCs from rhesus monkeys, 20 million	Cryopreservation

[Crab-eating Macaque Serum and Plasma]

1. Cynomolgus monkeys from a health-untreated, drug-naïve population;

2. Serum was collected using vacuum blood collection tubes containing a separation gel; the blood sample was normal and free of hemolysis; the serum was freshly collected and had not been thawed.

Sample Number	Delivery Specifications	Delivery Format
HYS-CMP001C	Cryopreserved crab-eating macaque plasma, 1 mL	Cryopreservation
HYS-CMS001C	Cryopreserved crab-eating macaque serum, 1 mL	Cryopreservation