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21

2023-11

Hycells Recruitment | Continuous Exploration and Innovation

Shanghai University is a comprehensive university under the jurisdiction of the Shanghai Municipal Government. It is a key institution designated for China’s “Double First-Class” initiative and the national “Project 211,” as well as one of the first batch of high-level local universities in Shanghai and a model institution for deepening reform in innovation and entrepreneurship education.

2023-11-21

He Yousheng

09

2023-11

New Product Trial | More Convenient and Efficient IL-15 NK Cell Expansion Reagent (Stromal Cells)

Immunotherapy is currently one of the most promising approaches for cancer treatment, with natural killer (NK) cells emerging as particularly promising effector cells. Immune cells are broadly categorized into adaptive and innate components. Innovative therapeutics targeting adaptive immune cells include cytotoxic T lymphocytes (CTLs), tumor-infiltrating lymphocytes (TILs), chimeric antigen receptor T cells (CAR-T cells), and T-cell receptors engineered T cells (TCR-T cells). Among these, CAR-T therapy is currently the most actively pursued modality; however, following CAR-T cell infusion, patients may experience two major severe adverse effects: cytokine release syndrome and neurotoxicity. Although CAR-T therapy achieves high rates of complete remission, it is associated with immune cell exhaustion, which can lead to disease relapse, and its efficacy against solid tumors remains limited due to off-target effects.

2023-11-09

He Yousheng

31

2023-10

Hycells Birthday Party | Love and Peace

Quarterly birthday celebrations have become a cherished tradition for our team, providing the perfect opportunity to come together, shake off the stresses and strains of daily work, and create a haven where both body and mind can find rest and rejuvenation.

2023-10-31

He Yousheng

21

2023-09

Little “Life” Makes Sense (V) | The Immune Scavenger—Macrophages

Macrophages are white blood cells residing in tissues, derived from monocytes, which in turn originate from precursor cells in the bone marrow. Both macrophages and monocytes are phagocytic cells that participate in both non-specific defense (innate immunity) and specific defense (cell-mediated immunity) within the body. Their primary functions include phagocytosing cellular debris and pathogens—either as tissue-resident or circulating cells—and activating lymphocytes and other immune cells to mount a response against these pathogens.

2023-09-21

He Yousheng

21

2023-09

Issue 1 | Sharing of CAR Positive Rate Testing Data

In 2010, two patients with hematologic malignancies became the first participants in a clinical trial of CAR-T cell therapy at the Perelman School of Medicine at the University of Pennsylvania, and their cancers achieved complete remission that same year. More than a decade later, research published in Nature and based on up to 10 years of follow-up data indicate that CAR-T cells can still be detected in patients’ bodies 10 years after infusion. Owing to their high selectivity, localized high concentrations, and customizable nature, cell therapies have ushered in a new chapter in cancer immunotherapy.

2023-09-21

He Yousheng

08

2023-09

Themed Salon | Antibody Discovery: The First Step in Developing Novel Antibody Drugs

Antibody therapeutics currently represent the fastest-growing segment within the biopharmaceutical industry and are a major focus of global drug discovery and development. This rapid advancement is driven by technological innovations, including diverse display technologies, transgenic humanized animal models, single-cell PCR, and single-cell sequencing.

2023-09-08

He Yousheng
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