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21

2024-10

Small “Life” Makes Sense (8) | Pre-Screening of Reconstructed Humanized Hu-PBMC Mouse Strains

As an advanced experimental animal model, humanized immune system mice have demonstrated tremendous potential and practical value in biomedical research and drug development in recent years. The generation of such mice typically relies on immunodeficient mouse models, in which human hematopoietic stem cells (HSCs), peripheral blood mononuclear cells (PBMCs), or other immune tissues are transplanted into these mice to reconstruct a human immune system, thereby mimicking human immune characteristics and pathological processes.

2024-10-21

He Yousheng

27

2024-06

Small “Life” Makes Sense (7) | Detection Antibodies for Fusion Proteins, Single-Chain Variable Fragments (scFv), and Bispecific Antibody Flexible Linkers (G4S)n

Last year, Hycells launched its blockbuster, universal CAR positivity assay antibody—Anti-G4S linker—which quickly won widespread recognition and collaboration from a growing customer base thanks to its ease of use and high precision. Anti-G4S linker is a universally applicable CAR positivity assay reagent that has been rigorously validated by numerous customers; by eliminating unnecessary and time-consuming steps, it accelerates the drug development process. It is suitable for detecting CARs with G4S linkers targeting any antigen ((G4S)n, where n ≥ 2), as well as for assays involving various antibody types that incorporate (G4S)n (where n ≥ 2). Moreover, it exhibits robust resistance to interference, remaining unaffected by antigen cross-reactivity and delivering more accurate in vivo CAR proportion measurements. Its exceptional sensitivity ensures outstanding detection performance even at very high or very low concentrations.

2024-06-27

He Yousheng

12

2024-04

Little “Life” Makes Sense (VI) | Immunogenicity Assessment of Peptide and mRNA Vaccines Based on Dendritic Cells

Peptides and mRNA have demonstrated significant potential for large-scale vaccine deployment due to their enhanced adaptability, making them suitable for combating rapidly mutating viruses or highly heterogeneous cancer types—this is made possible by the automated synthesis of diverse epitope sequences that has already been established for these platforms.

2024-04-12

He Yousheng

21

2023-09

Little “Life” Makes Sense (V) | The Immune Scavenger—Macrophages

Macrophages are white blood cells residing in tissues, derived from monocytes, which in turn originate from precursor cells in the bone marrow. Both macrophages and monocytes are phagocytic cells that participate in both non-specific defense (innate immunity) and specific defense (cell-mediated immunity) within the body. Their primary functions include phagocytosing cellular debris and pathogens—either as tissue-resident or circulating cells—and activating lymphocytes and other immune cells to mount a response against these pathogens.

2023-09-21

He Yousheng

06

2023-09

Little “Life” Makes Sense (IV) | The Advanced Intelligence Agent of Immunotherapy: Dendritic Cells

Dendritic cells (DCs) derive their name from the dendritic processes on their surface, which facilitate antigen capture and intercellular communication with other immune cells. As the most potent professional antigen-presenting cells (APCs), DCs efficiently engulf, process, and present antigens. Immature DCs exhibit robust migratory capacity, whereas mature DCs can effectively activate naïve T cells, thereby occupying a central role in initiating, regulating, and sustaining immune responses. Under normal conditions, DCs are present in low numbers, accounting for only about 1% of peripheral blood mononuclear cells in humans.

2023-09-06

He Yousheng

16

2023-08

Little “Life” Makes Sense (III) | The Rising Star of Immunotherapy: γδ T Cells

Immune cells, commonly known as white blood cells, include lymphocytes and various phagocytic cells. They are defined as lymphocytes and other cells capable of recognizing antigens and mounting specific immune responses. Based on their development and migration patterns, surface molecular characteristics, and functional properties, lymphocytes can be classified into T lymphocytes, B lymphocytes, and natural killer (NK) cells.

2023-08-16

He Yousheng
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