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Sample Service

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Sample Service

Recommended Information

Leukopak Collection Service

Leukopak is a concentrated blood fraction collected using a apheresis machine, primarily intended for the isolation of white blood cells (WBCs) from peripheral blood. WBCs are highly enriched in peripheral blood mononuclear cells (PBMCs), which consist mainly of T cells, B cells, NK cells, and monocytes. The WBC concentration in Leukopak is substantially higher—approximately 4–7 × 10^8 WBCs per milliliter—than that in whole blood, where the average is 5–7 × 10^6 WBCs per milliliter. In addition, the red blood cell (RBC) count in Leukopak is markedly reduced, with a ratio of about 2 RBCs to 1 WBC, whereas in whole blood the ratio is roughly 1,000 RBCs to 1 WBC. Moreover, the purity and quality of the WBC fraction in Leukopak are far superior to those in whole blood, typically containing more than 20-fold the amount of PBMCs. PBMCs are highly valued for their applications in immunotherapy research, cell therapy process development, and clinical settings. Consequently, WBCs have become the preferred starting material for cell therapy research and drug development.

PBMC Isolation Service

PBMC (peripheral blood mononuclear cell) refers to mononuclear cells in peripheral blood, including lymphocytes, monocytes, dendritic cells, and a small number of other cell types such as hematopoietic stem cells. Based on the source of the sample, PBMC can be classified as whole-blood–derived PBMC or apheresis–derived PBMC. Apheresis–derived PBMC is a component blood product obtained by leukapheresis using an apheresis machine; the majority of cells in this fraction are PBMC, with only a small proportion of granulocytes and erythrocytes.

CD3+ Cell Sorting Service

CD3 is an important leukocyte differentiation antigen that is expressed on the surface of nearly all T cells. It consists of four genetic loci and six polypeptide chains, and serves as a membrane-associated antigen that forms part of the T-cell antigen receptor (TCR). Upon antigen–TCR engagement, CD3 mediates intracellular signal transduction, regulates T-cell differentiation—including the lineage commitment and activation of helper T cells and cytotoxic T cells—facilitates cytokine secretion and apoptosis, and influences ligand-receptor interactions, thereby playing a critical role in the diverse functional activities of T cells.

CD4+ Cell Sorting Service

CD4 cells refer to T lymphocytes that express the CD4 molecule on their surface; they are a crucial type of immune cell in the human body. Because HIV primarily targets CD4+ T cells, the results of CD4 cell count testing play an important role in assessing the efficacy of AIDS treatment and evaluating the patient’s immune function.

CD4+ Naive T Cell Sorting Service

Among helper T cells, naïve CD4+ T cells that have not yet been stimulated by antigens are designated as Th0. Upon maturation and activation, these cells can execute a variety of antigen-dependent effector functions. Based on their distinct functional profiles, CD4+ T cells can be classified into several Th cell subsets, including Th1, Th2, Th3, Treg, Tr1, Tfh, Th17, Th9, and Th22. These Th subsets engage in intricate interplay and coordinate their activities to exert immunoregulatory effects, thereby maintaining homeostasis of the organism.

CD8+ cytotoxic T cells

CD8+ cytotoxic T cells are considered the primary effector cells of anti-tumor immunity. Their restricted and antigen-specific recognition of tumor-associated antigens (TA) via class I MHC molecules, combined with their ability to produce perforin and other cytotoxins upon activation, enables them to induce tumor cell death while sparing normal cells.

Disease Sample Services

Heyousheng Biotechnology offers compliant collection services for a wide range of disease samples, supporting high-quality development in the pharmaceutical sector. Deliverable sample types include PBMCs, apheresis or whole blood samples, tissue samples, and paraffin-embedded blocks, among others.

Compliance Approval

Recruitment and Screening

Collect

Quality Control

Sample Delivery

Compliance Approval

In strict accordance with regulatory requirements set forth in the Regulations on the Administration of Human Genetic Resources, the Good Clinical Practice for Drug Clinical Trials, and other relevant laws and regulations, we conduct compliant project applications and approvals to comprehensively ensure that our services are lawful and compliant.

Recruitment and Screening

We have established stable partnerships with multiple recruitment agencies and a robust re-recruitment mechanism, rigorously screening donors based on nationality, occupation, health status, and other criteria to ensure sample quality from the very source.

Collect

Establish long-term, stable partnerships with fully accredited and well-managed hospitals, equipped with dedicated personnel and specialized equipment to ensure the safety and stability of the entire blood-collection process.

Quality Control

Establish a comprehensive quality control system that ensures end-to-end recording and full traceability of all quality-control data, thereby guaranteeing the stability and reliability of service delivery.

Sample Delivery

Entrust a professionally qualified cold-chain logistics company to ensure the rapid and secure delivery of samples.

Heyousheng Biotechnology offers clients compliant collection services for a wide range of disease-specific samples, thereby supporting high-quality development in the pharmaceutical sector. Deliverable sample types include PBMCs, apheresis or whole blood samples, tissue specimens, and paraffin-embedded blocks, covering the following disease categories:

Disease samples (whole blood, tissue, paraffin blocks)

Chronic diseases: hypertension, diabetes, chronic respiratory diseases, etc.
Neurological disorders: AD/PD/genetic neurological disorders, etc.
Autoimmune diseases: PBC, AIH, IBD, MS, SLE, AS, etc.
Solid tumors: lung cancer, colorectal cancer, breast cancer, liver cancer, gastric cancer, pancreatic cancer, and others.
Hematologic malignancies: leukemia, multiple myeloma, and non-Hodgkin lymphoma
Viral infectious diseases, among others.

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Platform Advantages

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1. Clinically compliant data collection services with end-to-end traceability

Strictly comply with regulations : Complies with the Regulations on the Administration of Human Genetic Resources, the Good Clinical Practice (GCP) for Drug Clinical Trials, and other relevant requirements, thereby ensuring that sample collection is lawful and compliant.

Fully traceable : Record the entire workflow of samples, from collection and transportation to storage and use, to ensure data authenticity, completeness, and traceability.

A comprehensive quality management system : Certified under the ISO 9001:2015 quality management system, meeting the clinical submission requirements of regulatory authorities such as the FDA and NMPA.

2. Personalized data collection solutions tailored to precisely meet research needs

Customize sample collection protocols based on research objectives (e.g., targeted therapy, immunotherapy, and studies of drug resistance mechanisms), and optimize sample types (fresh/frozen tissues, blood samples, etc.). Provide deep matching of clinical data, such as treatment history, pathological subtyping, and genetic testing results, to ensure that the PDX model accurately recapitulates the patient’s tumor characteristics.

3. Nationwide high-quality clinical resources ensure a high-quality source of samples.

Our collaborations span tertiary hospitals nationwide and high-quality GCP centers, ensuring compliant sample sourcing and comprehensive clinical data. A wide selection of cancer types to meet the needs of various research protocols.

4. Professional team ensures efficient completion of HGRAC/GCP compliance submissions.

Our team has extensive experience in GCP and HGRAC project management and submission, enabling us to efficiently complete human genetic resource registration, ethical review, and other related procedures. We provide end-to-end compliance support, including the design of informed consent forms and the execution of Material Transfer Agreements, to mitigate legal risks.

For more details on disease samples covered by HeYouSheng, please contact the business manager. Contact: Mr. Xie, 15201775322.

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